Club Brugge and Borussia Dortmund will hope to carry their domestic form into Matchday 1 as they look to get off to a perfect start in the revamped Champions League group stage.
With 36 teams competing in one league this season, each team will play eight matches in the battle to progress to the last 16.
After a slow start in the Belgian Pro League, the hosts are bound to be full of confidence after winning four games on the spin.
Dortmund, meanwhile, have picked up seven points from their first three Bundesliga games and will fancy their chances of leaving Belgium with three points.
Before you consider placing a football bet with Bet777, read on to check out our full preview of what is expected to be an action-packed affair at the Jan Breydel Stadium.
And do not forget that we offer a full range of betting markets on each and every Champions League game.
Club Brugge vs Borussia Dortmund
Wednesday, September 18, 8pm, TNT Sports
Jan Breydel Stadium, Bruges
Club Brugge vs Borussia Dortmund Preview
After suffering defeat in the Belgian Super Cup, Club Brugge picked up just one point from their opening three league games.
But they have since recorded four wins on the spin, including a 3-0 success over ground-sharing rivals Cercle Brugge.
With clean sheets in their last two outings, Nicky Hayen’s side are on a role and home advantage could prove decisive on Matchday 1.
Dortmund have played half the number of games the hosts have but are already looking in good shape.
Home wins over Eintracht Frankfurt and Heidenheim were sandwiched either side of a goalless draw at Werder Bremen, which suggests they still have a little work to do on their travels.
Latest Champions League Betting Odds
*All odds are subject to change
Considering Club Brugge have yet to lose a league game at the Jan Breydel Stadium this season, 3.45 for a home win appears to be a smart bet. But if you fancy Dortmund to continue their impressive start to the campaign, 2.02 for an away win is not to be sniffed at.
Club Brugge vs Borussia Dortmund Betting Tips
Despite failing to get off the mark this term, Dortmund ace Maximilian Beier is a tempting 6.00 in the first goalscorer market. But team-mate Karim Adeyemi, priced at 7.70, should catch your eye after bagging two goals and notching one assist in three Bundesliga outings this term.
Bet Builder Quick Bets: Andreas Olsen to score anytime, Club Brugge to win & over 1.5 goals – 8.00
If you fancy the home side to win, this bet builder may be right up your street. With seven Belgian Pro League appearances under his belt this term, Andreas Olsen has already netted three goals and provided one assist.
When you choose 777 Sport, you can enjoy a whole range of top-quality sports and markets. Whatever you choose, always remember to bet responsibly. Here at 777, player wellbeing is our number one priority – check out our Responsible Gambling tips and tools page for more information.
